- Matrix metalloproteinase (MMP) substrate discovery using proteomic and yeast two-hybrid approaches.
- Protease degradomics and associated mass spectrometric and protease chip technology development.
- Structural and functional analysis of MMPs and tissue inhibitor of metalloproteases (TIMPs).
- De novo protease construction: Engineering novel catalytic activity onto inert scaffolds.
- Chemokine processing by MMPs and its role in cancer, HIV, and inflammation.
- Basic research in these themes is applied to understanding the molecular diagnosis and pathogenesis of cancer, chronic inflammatory diseases including arthritis and periodontitis, and HIV.
- October 29, 2015: Spotlight on human pulp (CBR Blog, UBC Dentistry)
- March 12, 2015: The Green Side of CBR – The Overall Lab and the CBR care about sustainability (CBR Blog)
- December 16, 2014: The Overall lab characterizes a new digestion enzyme for proteomics (CBR Blog, UBC Dentistry)
- May 13, 2014: UBC-developed anti-viral drug enhances immune system (Vancouver Sun)
- May 12, 2014: UBC scientists find new way to mobilize immune system against viruses
- April 25, 2014: Dr. Christopher Overall, recipient of CNPN – Tony Pawson Proteomics Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community
- March 20, 2013: Dr. Christopher Overall wins IADR distinguished scientist award for research in oral biology
- January 22, 2013: Master switch discovery could provide road map for treatment of arthritis and other inflammatory diseases. Featured on Global BC News.
- November 06, 2008: Dentistry Research: The Overall Approach