The University of British Columbia
UBC - A Place of Mind
The University of British Columbia
The Overall Lab
  • Home
  • People
    • Christopher M. Overall
    • Reinhild Kappelhoff
    • George (Georgina) Butler
    • Nestor Solis
    • Jacob Rozmus
    • Peter Bell
    • Isabel Pablos
    • Yoan Machado
    • Pirjo Astrom
    • Simon Abbey
    • Parker Jobin
  • Research
    • Interests
    • Highlights
  • Publications
  • Resources
    • Protocols and SOPs
    • CLIP-CHIP™
    • TAILS
    • TopFIND
    • WebPICS
  • InterfeRx
  • Alumni
    • Antoine Dufour
    • Ulrich Eckhard
    • Nikolaus Fortelny
    • Pitter Huesgen
    • Theo Klein
    • Laura Kuhlmann
    • Philipp Lange
    • Jennifer Mark
    • Giada Marino
    • Karen Nguyen
    • Tobias Pasqualon
    • Anna Prudova
    • Vinotheni Rajendran
    • Shreyas Rangan
    • Lindsay Rogers
    • Yili Wang
  • Contact
  • Protease Web

    Proteases do not operate alone, but in linear pathways and amplification cascades (with a one-way flow of information) or in regulatory circuits (with information feedback). By interconnecting between different protease classes, families and pathways, an interconnecting web that we term the ‘protease web’ is formed. The protease web is not in equilibrium but in constant […]

  • The Centre for Blood Research

    Who we are The Centre for Blood Research (CBR) is a multidisciplinary biomedical research institute, situated primarily at the University of British Columbia (UBC) and affiliated teaching hospitals, with nodes at the University of Northern British Columbia and at the University of Victoria. Over 40 research groups at the CBR are working together, using a […]

  • Vancouver

    Vancouver (pronounced /væn.ˈkuːvər/) is a coastal city located in the Lower Mainland of British Columbia, Canada.

Research Interests

  • Matrix metalloproteinase (MMP) substrate discovery using proteomic and yeast two-hybrid approaches.
  • Protease degradomics and associated mass spectrometric and protease chip technology development.
  • Structural and functional analysis of MMPs and tissue inhibitor of metalloproteases (TIMPs).
  • De novo protease construction: Engineering novel catalytic activity onto inert scaffolds.
  • Chemokine processing by MMPs and its role in cancer, HIV, and inflammation.
  • Basic research in these themes is applied to understanding the molecular diagnosis and pathogenesis of cancer, chronic inflammatory diseases including arthritis and periodontitis, and HIV.

News Releases

    • UBC-Flintbox HPG-ALD Polymer ordering page click to order HPG-ALD Polymer 
    • June 6, 2019: CBR Postdoc and Research Associate Retreat at Loon Lake – CBR Blog by George Butler
    • April 3, 2019: George Butler and Chris Overall speak at this years Norman Bethune Symposium (CBR Blog)
    • February 11, 2019: Overall Lab bonding at NedCad: Blood is Bonding – CBR blog by George Butler (check out our fun outing at YouTube)
    • May 17, 2016: Team Sheldon (aka The Overall Labs Green Team) wins UBC Lab Energy Challenge 2016 (TEAM SHELDON – Shut the sash)
    • December 10, 2015: Let Rare Mutations Speak: Novel Mechanisms in Immune System Regulation (CBR Blog).
      TAILS N-terminomics TMT10plex data featured by Accelerating Proteomics and Thermo Scientific.
    • October 29, 2015: Spotlight on human pulp (CBR Blog, UBC Dentistry News).
    • September 2, 2015: Conference Reports: Gordon Research Seminar and Conference on Matrix Metalloproteinases (CBR Blog).
    • July 30, 2015: Don’t be a square – think outside the box! (CBR Blog).
      “Let’s break out of that box, leave dogma and “what is known” behind, and have the courage to look at the unexpected. This is where the breakthroughs are waiting: not where people have been looking for decades but where no one has thought to look yet.”
    • July 16, 2015: Conference Reports: EuPA Annual Conference and MaxQuant Summer School (CBR Blog).
    • May 21, 2015: Picornaviruses cleave host’s proteins to facilitate viral infection (CBR Blog).
    • May 3, 2015: The Overall Lab at the Pacific Coast Protease Spring School – Desert Hot Spring, California
    • March 12, 2015: The Green Side of CBR – The Overall Lab and the CBR care about sustainability (CBR Blog).
    • December 16, 2014: The Overall lab characterizes a new digestion enzyme for proteomics (CBR Blog, UBC Dentistry News, @IBMB-CSIC).
    • September 16, 2014: UBC Green Labs Project featuring our lab manager Dr. Reinhild Kappelhoff (UBC Risk Management Services @Youtube).
    • May 13, 2014: UBC-developed anti-viral drug enhances immune system (Vancouver Sun, InterfeRx).
    • May 12, 2014: UBC scientists find new way to mobilize immune system against viruses (UBC News, InterfeRx, feature also at World Pharma News).
    • April 25, 2014: Dr. Christopher Overall, recipient of CNPN – Tony Pawson Proteomics Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community (CBR News).
    • March 20, 2013: Dr. Christopher Overall wins IADR distinguished scientist award for research in oral biology (UBC Dentistry News).
    • January 22, 2013: Master switch discovery could provide road map for treatment of arthritis and other inflammatory diseases (UBC News). Featured on Global BC News and by Linda Aylesworth on Twitter.
    • February 17, 2012: Mapping proteins key to human health and immune system (UBC News).
    • November 1, 2011: Lifetime Achievement Award for Dr. Christopher Overall (UBC Dentistry New, IPS Newsletter).
    • November 06, 2008: Dentistry Research: The Overall Approach (UBC Dentistry News)

For more news and updates, just follow us on Twitter and Facebook!

Chris Overall-Lab-Logo-UBC

The Overall Lab
University of British Columbia
2350 Health Sciences Mall, Room 4.420
Vancouver, BC Canada V6T 1Z3
Tel 1 604 822 3561
Fax 1 604 822 7742
Website clip.ubc.ca/
Email chris.overall@ubc.ca
Find us on
   
Back to top
The University of British Columbia
  • Emergency Procedures |
  • Terms of Use |
  • Copyright |
  • Accessibility