Tobias PasqualonTobias Pasqualon - Chris Overall Lab

Post-doctoral Fellow

Centre for Blood Research
University of British Columbia
2350 Health Sciences Mall
Vancouver, BC, V6T 1Z3, Canada

Lab: #4.420; Bench 8. 
Phone: +1-604-822-3561 (lab)
Email: tbd

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  • Since 2016: Postdoctoral Research Fellow, The Overall lab, University of British Columbia (Vancouver, Canada)
  • 2012 – 2015: Doctoral dissertation (Dr.rer.nat.), Institute of Pharmacology and Toxicology, University Hospital RWTH Aachen (Aachen, Germany)
  • 2010 – 2012: Master of Science (M.Sc.), Molecular and Applied Biotechnology, RWTH Aachen University (Aachen, Germany)
  • 2008 – 2010: Bachelor of Applied Science (B.AS) , Hogeschool Zuyd (Heerlen, The Netherlands) and Grünenthal GmbH (Aachen, Germany)
  • 2005 – 2008: Apprenticeship as Biological Laboratory Assistant, Grünenthal GmbH (Aachen, Germany)


  • Pasqualon T., Lue, H., Groening S., Pruessmeyer J., Jahr H., Denecke B., Bernhagen J., Ludwig A. Cell surface syndecan-1 contributes t+o binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. 2016 February 04; PMID: 26852939.
  • Pasqualon T., Pruessmeyer J., Jankowski V., Babendreyer A., Groth E., Schumacher J., Koenen A., Weidenfeld S., Schwarz N., Denecke B., Jahr H., Jankoswki J., Dreymueller D., Andreas Ludwig. A cytoplasmic c-terminal fragment of syndecan-1 is generated by sequential proteolysis and anatagonizes syndecan-1 dependent lung tumor cell migration. Journal Oncotarget. 2015 Oct 13;6(31):31295-312.
  • Pasqualon T., Pruessmeyer,J., Weidenfeld S., Babendreyer A., Groth E., Schumacher J., Schwarz N., Denecke B., Jahr H., Zimmermann H., Dreymueller D., Ludwig A. A transmembrane c-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Journal of Cellular and Molecular Life Sciences. 2015 Oct;72(19):3783-801
  • Pruessmeyer J., Hess F.M., Ahlert H., Groth E., Pasqualon T., Schwarz N., Nyamoya S., Kollert J., van der Vorst E., Donners M., Martin C., Uhlig S., Saftig P., Dreymueller D., Ludwig A. Leukocytes require the metalloproteinase ADAM10 but not ADAM17 for cell migration and for inflammatory leukocyte recruitment into the alveolar space. Blood. 2014 Jun 26;123(26):4077-88.
  • Soppa U., Schumacher J., Florencio Ortiz V., Pasqualon T., Tejedor F.J., Becker W. The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. Cell Cycle. 2014;13(13):2084-100.